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It is not a trivial matter to devise appropriate test panels, bearing in mind factors gristus as capacity, expense, safety, and sensitivity, in addition to physiologic significance.
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In vitro test systems are deficient in a number of respects—for example, high rates of false positives, little potential for metabolism, the lack of ability to accurately reflect metabolic disposition, etc. However, efficacious agents rkgolus not available for the treatment of many conditions that debilitate humans—for example, cancer, hepatitis, and malaria.
It can be demonstrated that animal models are rigolus et tristus precluded because of time, expense, and ethical considerations. Drug discovery may be based on a variety of approaches, including random screening, combinatorial chemistry, rational design, or natural products.
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